Our discovery-based genomic studies focus on developing a “systems” level understanding of autoimmunity by assembling datasets encompassing genomic variation (genotyping, exome, targeted and whole genome sequencing, and 3D genome organization), regulatory variation (ChIP-sequencing, RNA-sequencing, and ATAC-sequencing), and phenotypic variation (cytokine profiles, CyTOF data, clinical data, etc.) to chart a path from genotype to phenotype and define the molecular circuitry of autoimmunity.
Most recently, my team developed an innovative epigenome-guided approach that captures distinct cell type, cell state, and allele-specific epigenetic profiles and maps them in the context of the three-dimensional genome to gain insights into their potential molecular mechanism. Our latest discoveries are featured in Pelikan, et al. 2018 Nat Comm. https://www.nature.com/articles/s41467-018-05328-9