Dr. Gaffney was awarded a new 2-yr award from the Lupus Research Alliance (LRA) to use single-cell ATAC sequencing (sciATAC-seq) to characterize the epigenome and transcriptome features in human subjects with SLE in order to identify putative epigenome-transcriptome biomarker modules.
Our graduate student, Jaanam Gopalakrishnan, was recognized as an outstanding graduate student leader at the Annual 2020 OUHSC Student Award Ceremony. During her time as a graduate student, Jaanam not only dedicated her time to academics and outstanding research but has also served in many leadership roles for the graduate college, OUHSC campus, and our local community. As a testament to her dedication and hard work in the lab, she has received numerous scientific achievement awards. On April 20, 2020, Jaanam’s leadership skills and service were also recognized, and we couldn’t be more proud of her accomplishments. We would like to congratulate Jaanam as the new recipient of the:
- 2020 O Ray Kling Award for Outstanding Graduate Student Leadership (OUHSC Graduate College)
- 2020 Joseph J Freddy Outstanding Overall Senior Leadership Award (OUHSC Student Affairs)
We are excited to announce our newest publication, which reveals important new insights into the functional complexity of the SLE-associated TNIP1 risk haplotype. Pasula, et al. Arthritis Rheumatol. 2019.
Dr. Gaffney was awarded a new R01 research grant from the NIH to study how the genetic risk variants associated with SLE influence disease phenotype. Dr. Gaffney’s research team recently published a research manuscript highlighting how inherited genetic risk variants influence gene expression by altering how the chromatin folds in 3D space (Pelikan, et al. 2018). Chromatin folding is a tightly regulated process that ensures the interactions between specific non-coding regulatory regions of DNA and the genes that they control.
Our new research grant, titled “Epigenome-guided causal variant discovery and mechanisms”, will use these findings as a launching pad to identify genetic risk variants in SLE that influence the chromatin network and drive changes in the expression of genes involved in SLE pathogenesis.
Our graduate student, Jaanam Gopalakrishnan, continues to be recognized for the outstanding research she is doing in our lab to characterize the role of UBE2L3 in lupus. Last week (3/29/19), Jaanam was recognized as one of 10 selected finalists for the 2019 OUHSC Biomedical Engineering Symposium Poster Competition. Congratulations Jaanam!
Dr. Gaffney was appointed Chair of the new Genes and Human Disease Research Program at the Oklahoma Medical Research Foundation! We are extremely excited about the new genomics and data science research opportunities that this step will bring to our Foundation.
If you want more information about how to join our exciting new adventure, please contact us!
Our postdoctoral fellow, Dr. Yao Fu, received the OMRF Postdoctoral Travel Award for her poster presentation, titled “Studying Chromatin Accessibility in Human SLE at Single-Cell Resolution“, at the 2019 OMRF Scientific Retreat. Dr. Fu has spearheaded our efforts to bring scATAC-seq to our research team and the OMRF community, with financial support from the Presbyterian Health Foundation.
Congratulations Yao! We are so proud of you!
The Gaffney Lab would like to thank the Presbyterian Health Foundation for their continued support of our ongoing mission to establish new state-of-the-art sequencing technologies in our lab.
Our newest award, titled “Developing proficiency in the sciATAC-seq technology“, aims to develop proficiency in a new method (sciATAC-seq) that uses combinatorial indexing of single cells to evaluate chromatin accessibility regulomes of SLE patients and controls. The method allows researchers to pool thousands of cells while maintaining the individual identity of each cell, thereby greatly reducing the single-cell sequencing cost.
The Gaffney lab is honored to welcome our newest and tiniest honorary member!
Congratulations Graham, Mandi, and the entire Wiley family on the newest edition!
We are proud to announce that our newest review on the role of the 3D genome in complex disease genetics is now published and available via open access in PubMed.
Go check it out at https://protect-us.mimecast.com/s/HZrGC68G6GCrXxkLfp86du?domain=em.rdcu.be